EFFECT CURCUMIN PLANT ON LIVER OF RATS TREATED WITH TRICHLOROETHYLENE

Abstract

Background & Aims: Curcumin (CCM), a plant phenolic compound, is widely used as a spice and coloring agent in food. Recently, CCM, had been considered to possess antioxidant activities. This study aimed to investigate whether CCM, protect against trichloroethylene (TCE)- induced hepatotoxicity and to demonstrate its possible mode of action. Methods: A group of male rats were treated with TCE (5mg/1000 ml of drinking water) to induce liver injury. The CCM group was fed 25 g mixed with the diet (2.5Kg) concomitantly with 5 mg TCE/1000ml drinking water, for 8 weeks. The rat were killed after treatment period of 8 weeks, and samples of livers tissue were fixed immediately in 10% formalin. Results: Histopathological changes It was obviose that TCE administration has shown dramatic injures in the liver tissues, and the treatment with curcumin can activate these injures to advanced level.