Molecularly imprinted polymer ( poly-pyrrole ) modified glassy carbon electrode on based electrochemical sensor for the Sensitive Detection of Pharmaceutical Drug Naproxen

Abstract

Abstract: In this study, A simple and efficient new electrochemical sensor based on molecularly imprinted polymer(MIP) has been developed for selective detection of the Naproxen(NAP). The sensor was prepared by electropolymerization via cyclic voltammetry (CV) of pyrrole onto a glassy carbon electrode (GCE) in the presence of (NAP) molecules. The extraction of (NAP) molecules embedded in the polymeric matrix was carried out by overoxidation in sodium hydroxide medium using CV. Various important parameters affecting the performance of the imprinted film (MIP) coated sensor were studied and optimized using differential pulse voltammetry (DPV). The highest anodic signal of NAP was obtained in a phosphate buffer solution of pH 7.0. The linear response range for NAP was 9.2 × 10–7 M to 3.0 ×10−5 M, and the limit of detection was as low as 3.0 × 10-9 M. The results of our investigation indicate that the MIP sensor was useful for the determination of NAP with excellent selectivity, high sensitivity, repeatability, and reproducibility.