Hepatoprotective Potential of Propolis on Carbontetrachloride-Induced Hepatic Damages in Rats
Abstract
The human body is exposed nowadays to increasing attacks by toxic compounds in polluted air, industrially processed foods, alcohol and drug consumption that increase liver toxicity, leading to more and more severe cases of hepatic disorders. The paper aims to examine the effects of bees propolis against liver damage in wistar rats with carbon tetrachloride induced hepatotoxicity, by analyzing the biochemical determination (total protein, albumin, total bilirubin levels) and antioxidant enzymatic (nitric oxidase (NO), Glutathione-S-transferase (GST). The experiment was carried out on four groups of female wistar rats. Hepatic lesions were induced by intraperitoneal injection carbon tetrachloride (dissolved in an equal volume of olive oil) 0.5ml/kg were administered three times per week for two weeks. Biochemical results reveal that therapy with propolis has a positive effect on improving the parameters such as; total protein, albumin, total bilirubin levels and antioxidants such as; nitric oxidase, Glutathione-S-transferase.