| dc.description.abstract | Background & Aims: Curcumin (CCM), a plant phenolic compound, is
widely used as a spice and coloring agent in food. Recently, CCM, had
been considered to possess antioxidant activities. This study aimed to
investigate whether CCM, protect against trichloroethylene (TCE)-
induced hepatotoxicity and to demonstrate its possible mode of action.
Methods: A group of male rats were treated with TCE (5mg/1000 ml of
drinking water) to induce liver injury. The CCM group was fed 25 g
mixed with the diet (2.5Kg) concomitantly with 5 mg TCE/1000ml
drinking water, for 8 weeks. The rat were killed after treatment period of
8 weeks, and samples of livers tissue were fixed immediately in 10%
formalin.
Results: Histopathological changes
It was obviose that TCE administration has shown dramatic injures
in the liver tissues, and the treatment with curcumin can activate these
injures to advanced level. | en_US |
